Phenotypes Associated with This Genotype

Genotype
MGI:3620569

• Allelic Composition: Vcam1^tm1Dmil/Vcam1^tm1Dmil
• Genetic Background: C.129S4-Vcam1^tm1Dmil

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:69597 )

• Background Sensitivity: 24-25% embryonic survival; embryonic lethality increases on a 129 or C57BL/6 congenic background

cellular

decreased cell chemotaxis ( J:227109 )

• reduced recruitment of leukocytes into peritoneal cavity as compared to wild-type following IP challenge with ovalbumin

• numbers of monocytes, macrophages and lymphocytes recovered from the peritoneal cavity are reduced, but not neutrophils or eosinophils

• total cell numbers are not reduced

embryo

abnormal chorioallantoic fusion ( J:69597 )

• more than 50% of homozygotes at E9.5 and E12.5 display chorioallantoic fusion defects

immune system

increased leukocyte cell number ( J:69597 )

• blood leukocytes are elevated 1.6 and 1.4 fold at 8 months and 15 months of age, respectively

increased B cell number ( J:69597 )

• absolute numbers of B lymphocytes are elevated at 8 months of age

increased T cell number ( J:69597 )

• absolute numbers of T lymphocytes are elevated at 8 months of age

increased monocyte cell number ( J:69597 )

• absolute numbers of monocytes are elevated at 8 months of age

hematopoietic system

increased leukocyte cell number ( J:69597 )

• blood leukocytes are elevated 1.6 and 1.4 fold at 8 months and 15 months of age, respectively

increased B cell number ( J:69597 )

• absolute numbers of B lymphocytes are elevated at 8 months of age

increased T cell number ( J:69597 )

• absolute numbers of T lymphocytes are elevated at 8 months of age

increased monocyte cell number ( J:69597 )

• absolute numbers of monocytes are elevated at 8 months of age