Phenotypes Associated with This Genotype

Genotype
MGI:3620568

• Allelic Composition: Vcam1^tm1Dmil/Vcam1^tm1Dmil
• Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:69597 )

• Background Sensitivity: 29% embryonic survival; embryonic lethality increases on a 129 or C57BL/6 congenic background

embryo

abnormal chorioallantoic fusion ( J:69597 )

• more than 50% of homozygotes at E9.5 and E12.5 display chorioallantoic fusion defects

hematopoietic system

increased monocyte cell number ( J:69597 )

• small yet significant elevation in monocytes at 2-4 months of age

immune system

increased monocyte cell number ( J:69597 )

• small yet significant elevation in monocytes at 2-4 months of age