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Phenotypes Associated with This Genotype
Genotype
MGI:3620461
Allelic
Composition
Kcnk3tm1Sgb/Kcnk3tm1Sgb
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk3tm1Sgb mutation (1 available); any Kcnk3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• delayed mastering of balance on accelerating rotarod assay (J:103747)
• more frequent falls in narrow beam-walking test (J:103747)
• delayed mastering of balance on accelerating rotarod assay (J:103747)
• more frequent falls in narrow beam-walking test (J:103747)

homeostasis/metabolism
• females, but not males, have severely increased plasma aldosterone levels under basal conditions (J:188335)
• potassium-rich diet does not further increase plasma aldosterone levels (J:188335)
• females, but not males, have severely increased plasma aldosterone levels under basal conditions (J:188335)
• potassium-rich diet does not further increase plasma aldosterone levels (J:188335)

Mouse Models of Human Disease
OMIM ID Ref(s)
Glucocorticoid-Remediable Aldosteronism; GRA 103900 J:188335


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory