Phenotypes Associated with This Genotype

Genotype
MGI:3620461

• Allelic Composition: Kcnk3^tm1Sgb/Kcnk3^tm1Sgb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:103747 )

• delayed mastering of balance on accelerating rotarod assay

• more frequent falls in narrow beam-walking test

homeostasis/metabolism

increased circulating aldosterone level ( J:188335 )

♀ • females, but not males, have severely increased plasma aldosterone levels under basal conditions

♀ • potassium-rich diet does not further increase plasma aldosterone levels