Analysis Tools
immune system
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• at 1 week after transplant of bone marrow cells or PBMC from swine donors in irradiated transgenic SCID recipient mice, the percentage of porcine cells in the WBC in medronate-liposome treated (for depletion of macrophages) recipients is 10x greater than in PBS treated controls
(J:94302)
• chimerism in medronate-liposome treated mice at 8 weeks post-transplant is 60% in the marrow compared to less than 30% in PBS treated controls
(J:94302)
• engraftment of porcine bone marrow cells after bone marrow transplant into irradiated transgenic SCID mice is achieved and porcine hematopoesis is maintained at 7 weeks post-transplant compared to non transgenic littermates which lose porcine chimerism completely
(J:106416)
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