Phenotypes Associated with This Genotype

Genotype
MGI:3620196

• Allelic Composition: Plp1^tm3Wst/Plp1^tm3Wst
• Genetic Background: B6.129S1-Plp1^tm3Wst

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal myelin sheath morphology ( J:105188 )

♀ • myelin sheaths are compacted; however, myelin sheaths with remaining oligodendrocyte cytoplasm are detected

♀ • a few degenerating myelin sheaths are seen on the optic nerve

abnormal optic nerve morphology ( J:105188 )

♀ • a few degenerating myelin sheaths and degenerating nerve fibers are seen on the optic nerve

abnormal myelination ( J:105188 )

♀ • redundant myelin is occasionally seen; however, small diameter axons are myelinated

vision/eye

abnormal optic nerve morphology ( J:105188 )

♀ • a few degenerating myelin sheaths and degenerating nerve fibers are seen on the optic nerve