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Phenotypes Associated with This Genotype
Genotype
MGI:3620124
Allelic
Composition
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
Genetic
Background
involves: 129S4/SvJae * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd80tm1Shr mutation (11 available); any Cd80 mutation (33 available)
Cd86tm2Shr mutation (2 available); any Cd86 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 9 weeks, all islets isolated from male and female homozygous mice showed high infiltration, whereas in wild-type NOD mice, only 10% and 3% of islets obtained from female and male mice displayed severe insulitis; no insulitis is detected at 4 weeks and at 6 weeks most islets aren't infiltrated
• there is a profound decrease in numbers of CD4+CD25+ T cells in homozygotes compared to wild-type with levels lower than in CD28-null mice on a NOD background
• in T cells and supernatants collected after stimulation with antil-CD3, production of all cytokines is reduced compared to wild-type levels
• almost 100% of homozygous mice become diabetic (blood glucose >300 mg/dl on 2 consecutive measurements) by 18 weeks of age, compared to 70% of female and 20% of male wild-type NOD controls or 40% of female and 10% of male wild-type mice

endocrine/exocrine glands
• at 9 weeks, all islets isolated from male and female homozygous mice showed high infiltration, whereas in wild-type NOD mice, only 10% and 3% of islets obtained from female and male mice displayed severe insulitis; no insulitis is detected at 4 weeks and at 6 weeks most islets aren't infiltrated

hematopoietic system
• there is a profound decrease in numbers of CD4+CD25+ T cells in homozygotes compared to wild-type with levels lower than in CD28-null mice on a NOD background

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:61905


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory