Mouse Genome Informatics
cx
    Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr

involves: 129S4/SvJae * NOD
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• at 9 weeks, all islets isolated from male and female homozygous mice showed high infiltration, whereas in wild-type NOD mice, only 10% and 3% of islets obtained from female and male mice displayed severe insulitis; no insulitis is detected at 4 weeks and at 6 weeks most islets aren't infiltrated
• there is a profound decrease in numbers of CD4+CD25+ T cells in homozygotes compared to wild-type with levels lower than in CD28-null mice on a NOD background
• in T cells and supernatants collected after stimulation with antil-CD3, production of all cytokines is reduced compared to wild-type levels
• almost 100% of homozygous mice become diabetic (blood glucose >300 mg/dl on 2 consecutive measurements) by 18 weeks of age, compared to 70% of female and 20% of male wild-type NOD controls or 40% of female and 10% of male wild-type mice

endocrine/exocrine glands
• at 9 weeks, all islets isolated from male and female homozygous mice showed high infiltration, whereas in wild-type NOD mice, only 10% and 3% of islets obtained from female and male mice displayed severe insulitis; no insulitis is detected at 4 weeks and at 6 weeks most islets aren't infiltrated

hematopoietic system
• there is a profound decrease in numbers of CD4+CD25+ T cells in homozygotes compared to wild-type with levels lower than in CD28-null mice on a NOD background

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:61905