Mouse Genome Informatics
ht
    Col1a1Mov13/Col1a1+
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hearing/vestibular/ear
• profound and progressive hearing loss with age
• profound and progressive hearing loss with age

skeleton
• modulus of elasticity of cortical bone is lower
• disorganized cortical bone, with bone cells not organized in a normal osteonal pattern and diorganization of collagen within the cortex
• exhibit a significant difference in the load deformation response of bones at failure, indicating brittle and fragile bones, however stiffness is normal
• modulus of elasticity of cortical bone is lower

integument
• dermis contains unusually thin collagen fibers and collagen content in the dermis is reduced by about 50%

Mouse Models of Human Disease
OMIM IDRef(s)
Osteogenesis Imperfecta, Type I 166200 J:107045