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Phenotypes Associated with This Genotype
Genotype
MGI:3620065
Allelic
Composition
Neil1tm1Rsld/Neil1tm1Rsld
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Neil1tm1Rsld/Neil1tm1Rsld and wild-type mouse comparison

growth/size/body
• obese mice contain massive deposition of fat within the subcutis, retroperitoneum, mediastinum, and abdomen, with nearly complete encasement of most internal organs (J:106077)
• obese mice contain massive deposition of fat within the subcutis, retroperitoneum, mediastinum, and abdomen, with nearly complete encasement of most internal organs (J:106077)
• males, and to a lesser extent females, develop obesity at around 6-10 months of age (J:106077)
• although sublines at Oregon Health & Science University and University of Texas Medical branch exhibit severe obesity, one breeding pair of homozygotes raised at New York University appears normal, even at 1 year of age (J:106077)
• males, and to a lesser extent females, develop obesity at around 6-10 months of age (J:106077)
• although sublines at Oregon Health & Science University and University of Texas Medical branch exhibit severe obesity, one breeding pair of homozygotes raised at New York University appears normal, even at 1 year of age (J:106077)

adipose tissue
• obese mice contain massive deposition of fat within the subcutis, retroperitoneum, mediastinum, and abdomen, with nearly complete encasement of most internal organs (J:106077)
• obese mice contain massive deposition of fat within the subcutis, retroperitoneum, mediastinum, and abdomen, with nearly complete encasement of most internal organs (J:106077)
• sporadically observe reduced subcutaneous fat only in the colony at Oregon Health & Science University (J:106077)
• sporadically observe reduced subcutaneous fat only in the colony at Oregon Health & Science University (J:106077)

homeostasis/metabolism
• seen in 1 year old obese males but not in females (J:106077)
• seen in 1 year old obese males but not in females (J:106077)
• by 6 months of age, all males exhibit hyperleptinemia (J:106077)
• females at 1 year of age, display approximately 2.5-fold increase in leptin levels (J:106077)
• by 6 months of age, all males exhibit hyperleptinemia (J:106077)
• females at 1 year of age, display approximately 2.5-fold increase in leptin levels (J:106077)
• triglyceride levels are 1.4- and 1.3-fold elevated at 3 months and 1.7- and 1.4-fold elevated at 7 months of age in males and females, respectively (J:106077)
• triglyceride levels are 1.4- and 1.3-fold elevated at 3 months and 1.7- and 1.4-fold elevated at 7 months of age in males and females, respectively (J:106077)

liver/biliary system
• males display significantly increased levels of mitochondrial DNA damage and deletions in liver tissue (J:106077)
• males display significantly increased levels of mitochondrial DNA damage and deletions in liver tissue (J:106077)
• males exhibit marked hepatic steatosis with more than 50% of cellular contents being a mixture of micro- and macrovesicular globules, however do not observe inflammation or fibrosis (J:106077)
• steatosis is most prominent in the centrilobular regions (J:106077)
• females exhibit a much less severe steatosis than males (J:106077)
• males exhibit marked hepatic steatosis with more than 50% of cellular contents being a mixture of micro- and macrovesicular globules, however do not observe inflammation or fibrosis (J:106077)
• steatosis is most prominent in the centrilobular regions (J:106077)
• females exhibit a much less severe steatosis than males (J:106077)
• pale yellow-colored liver (J:106077)
• pale yellow-colored liver (J:106077)

renal/urinary system
• males, and to a lesser extent females, display cytoplasmic vacuolization of tubule cells causing distension in many epithelial cells of the proximal convoluted tubules (J:106077)
• males, and to a lesser extent females, display cytoplasmic vacuolization of tubule cells causing distension in many epithelial cells of the proximal convoluted tubules (J:106077)

immune system
• sporadically seen only in the colony at Oregon Health & Science University (J:106077)
• sporadically seen only in the colony at Oregon Health & Science University (J:106077)

reproductive system
• sporadically seen only in the colony at Oregon Health & Science University (J:106077)
• sporadically seen only in the colony at Oregon Health & Science University (J:106077)

skeleton
• sporadically seen only in the colony at Oregon Health & Science University (J:106077)
• sporadically seen only in the colony at Oregon Health & Science University (J:106077)

tumorigenesis
• sporadically observe cancers only in the colony at Oregon Health & Science University (J:106077)
• sporadically observe cancers only in the colony at Oregon Health & Science University (J:106077)

integument
• sporadically observe skin ulcerations only in the colony at Oregon Health & Science University (J:106077)
• sporadically observe skin ulcerations only in the colony at Oregon Health & Science University (J:106077)

Mouse Models of Human Disease
OMIM ID Ref(s)
Abdominal Obesity-Metabolic Syndrome 1; AOMS1 605552 J:106077


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory