Phenotypes Associated with This Genotype

Genotype
MGI:3620050

• Allelic Composition: Olig2^tm1Rth/Olig2^tm1Rth
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:75868 )

• no homozygous mice aare found at weaning age

behavior/neurological

no spontaneous movement ( J:75868 )

nervous system

decreased oligodendrocyte progenitor number ( J:75868 )

• formation of oligodendrocytes in spinal cord at E15.5 is ablated or severely retarded

abnormal hindbrain development ( J:75868 )

• no somatic motor neurons are detected in the hindbrain

decreased motor neuron number ( J:75868 )

• no motor neurons are detected at any level of the spinal cord at any stages of development

abnormal ventral interneuron 2 morphology ( J:75868 )

• there is an increase in V2 interneurons in the spinal cord; these expand ventrally into the motor neuron domain

respiratory system

abnormal breathing pattern ( J:75868 )

• mutant fetuses at E18.5 lack breathing activity

cellular

decreased oligodendrocyte progenitor number ( J:75868 )

• formation of oligodendrocytes in spinal cord at E15.5 is ablated or severely retarded