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Phenotypes Associated with This Genotype
Genotype
MGI:3620031
Allelic
Composition
Clip2tm1.1Gal/Clip2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clip2tm1.1Gal mutation (1 available); any Clip2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• adult female weight is 9% lower than in wild-type
• mild growth retardation during the first weeks of postnatal development that persists in adult females

nervous system
• average corpus callosum volume is smaller, however ventricle volumes are normal
• synaptic plasticity in the hippocampal CA1 region is lower

behavior/neurological
• in a contextual fear-conditioning test, show a smaller increase in average freezing time after foot shock than in wild-type, however no differences are seen in a cued fear-conditioning test or elevated zero-maze test, indicating hippocampal defects
• remain on an accelerating rotarod for significantly shorter periods

Mouse Models of Human Disease
OMIM ID Ref(s)
Williams-Beuren Syndrome; WBS 194050 J:78711


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory