Mouse Genome Informatics
ht
    Clip2tm1.1Gal/Clip2+
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size/body
• adult female weight is 9% lower than in wild-type
• mild growth retardation during the first weeks of postnatal development that persists in adult females

nervous system
• average corpus callosum volume is smaller, however ventricle volumes are normal
• synaptic plasticity in the hippocampal CA1 region is lower

behavior/neurological
• in a contextual fear-conditioning test, show a smaller increase in average freezing time after foot shock than in wild-type, however no differences are seen in a cued fear-conditioning test or elevated zero-maze test, indicating hippocampal defects
• remain on an accelerating rotarod for significantly shorter periods

Mouse Models of Human Disease
OMIM IDRef(s)
Williams-Beuren Syndrome; WBS 194050 J:78711