Phenotypes Associated with This Genotype

Genotype
MGI:3619923

• Allelic Composition: Tg(Myh6-Pik3ca)1Siz/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased myocardial fiber size ( J:62707 )

• myocytes exhibit an 18% decrease in mean cell size, with both the long and short axis lengths decreased

small heart ( J:62707 , J:119070 )

• heart weight/body weight ratio is decreased by 17% without changes in the size of other organs or overall body weight, however show no signs of heart failure or abnormal cardiac function after 1 year (J:62707)

decreased heart weight ( J:87944 )

increased response of heart to induced stress ( J:119070 )

• mice subjected to pressure overload with aortic banding exhibit an increase in left ventricle end-systolic and diastolic volumes and depressed systolic function, exaggerated cardiac hypertrophy, increased left ventricle chamber dimension, and increased cardiac fibrosis in the left ventricular wall

homeostasis/metabolism

increased response of heart to induced stress ( J:119070 )

• mice subjected to pressure overload with aortic banding exhibit an increase in left ventricle end-systolic and diastolic volumes and depressed systolic function, exaggerated cardiac hypertrophy, increased left ventricle chamber dimension, and increased cardiac fibrosis in the left ventricular wall

muscle

decreased myocardial fiber size ( J:62707 )

• myocytes exhibit an 18% decrease in mean cell size, with both the long and short axis lengths decreased