Phenotypes Associated with This Genotype

Genotype
MGI:3619922

• Allelic Composition: Tg(Myh6-Pik3r1/PIK3CA)BSiz/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:62707 )

• myocytes exhibit a 19% increase in mean cell size, with both the long and short axis lengths increased

enlarged heart ( J:62707 )

• hearts are about 20% larger

cardiac hypertrophy ( J:62707 )

• heart weight/body weight ratio is increased by 18% without changes in the size of other organs or overall body weight, however show no signs of heart failure after 1 year

abnormal heart left ventricle morphology ( J:62707 )

• significant increase in wall thickness in both the anterior and the posterior left ventricular (LV) walls, however observe no differences in LV diastolic or systolic diameter or fractional shortening, indicating normal cardiac function

decreased response of heart to induced stress ( J:62707 )

• mice subjected to pressure overload with aortic banding exhibit protection against pressure overload, with a trend for a reduction in left ventricle end-systolic volume and greater systolic function, blunted cardiac hypertrophy, reduced left ventricle chamber dimension, and decreased fibrosis in the left ventricular wall

• however, mice exhibit a hypertrophic response to swim exercise training similar to controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:62707 )

• mice subjected to pressure overload with aortic banding exhibit protection against pressure overload, with a trend for a reduction in left ventricle end-systolic volume and greater systolic function, blunted cardiac hypertrophy, reduced left ventricle chamber dimension, and decreased fibrosis in the left ventricular wall

• however, mice exhibit a hypertrophic response to swim exercise training similar to controls

muscle

increased myocardial fiber size ( J:62707 )

• myocytes exhibit a 19% increase in mean cell size, with both the long and short axis lengths increased

growth/size/body

enlarged heart ( J:62707 )

• hearts are about 20% larger

cardiac hypertrophy ( J:62707 )

• heart weight/body weight ratio is increased by 18% without changes in the size of other organs or overall body weight, however show no signs of heart failure after 1 year