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Phenotypes Associated with This Genotype
Genotype
MGI:3619915
Allelic
Composition
Nr4a2tm1Omc/Nr4a2+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2tm1Omc mutation (0 available); any Nr4a2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• significantly reduced (39%) dopaminergic neurons in the substantia nigra and ventral tegmental area

behavior/neurological
• rotarod performance reduced 32% at 15-19 months of age
• rotarod performance reduced 39% at 20-24 months of age
• increased locomotor performance at 2-10 months of age by 29-48%
• decreased locomotor performance by 27-50% after 15 months of age

homeostasis/metabolism
• levels normal at 2-10 months of age
• reduced 32% at 15-19 months and 42% at 20-24 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:607688
OMIM:610297
OMIM:613643
OMIM:614251
OMIM:PS168600
J:104902


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory