Phenotypes Associated with This Genotype

Genotype
MGI:3619513

• Allelic Composition: Avpr1a^tm1Sbhu/Avpr1a^tm1Sbhu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:105892 )

• decreased IgM^highIgD^high B cells in the spleen and increased IgM^lowIgD^high

increased B-1a cell number ( J:105892 )

• increased numbers of B-1a cells

abnormal immunoglobulin level ( J:105892 )

• increased response to T-cell dependent antigens (involving IgG1 and IgG2b)

• no difference in response to T-cell independent antigens

increased IgG2a level ( J:105892 )

• increased IgG2a levels in serum

decreased IgG2b level ( J:105892 )

• decreased IgG2b levels in serum

hematopoietic system

abnormal B cell differentiation ( J:105892 )

• decreased IgM^highIgD^high B cells in the spleen and increased IgM^lowIgD^high

increased B-1a cell number ( J:105892 )

• increased numbers of B-1a cells

abnormal immunoglobulin level ( J:105892 )

• increased response to T-cell dependent antigens (involving IgG1 and IgG2b)

• no difference in response to T-cell independent antigens

increased IgG2a level ( J:105892 )

• increased IgG2a levels in serum

decreased IgG2b level ( J:105892 )

• decreased IgG2b levels in serum