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Phenotypes Associated with This Genotype
Genotype
MGI:3619459
Allelic
Composition
Tg(IGL-MYC)3Hm/0
Genetic
Background
C57BL/6N-Tg(IGL-MYC)3Hm/Nci
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IGL-MYC)3Hm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice hemizygous for the transgene die between the ages of 2 and 6 months

immune system
• transgene hemizygotes develop severe lymphadenopathy, but only minimal splenomegaly

neoplasm
• hemizygous transgenics develop clonal B-lineage lymphomas; their spleens and lymph nodes contain "uniform populations of IgM+CD19+CD5-CD23- cells"

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Burkitt lymphoma DOID:8584 OMIM:113970
J:65245


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory