Analysis Tools
neoplasm
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• only 14% of male homozygous mutants develop hepatocellular tumors by 16-18 months of age compared with 20% age and sex matched controls
• in 14-day old male mutant and control littermates inject with N-diethylnitrosamine to induce tumors, 50% of wild-type mice and 20% of mutant mice showed hepatic tumors at 25-weeks post-injection; at 36 weeks after treatment, all wild-type and 90% of mutant mice developed tumors
• only 5% of female mutants treated with N-diethynitrosamine develop hepatic tumors by 3 weeks compared to 90% of treated wild-type females
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• treated male mutants show reduced size and lower numbers of tumors than treated wild-type
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• tumor multiplicity in mutant mice in response to carcinogen is 4-fold lower than in wild-type
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liver/biliary system
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• liver mass is 2-fold lower in carcinogen-treated mutant mice
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• only 14% of male homozygous mutants develop hepatocellular tumors by 16-18 months of age compared with 20% age and sex matched controls
• in 14-day old male mutant and control littermates inject with N-diethylnitrosamine to induce tumors, 50% of wild-type mice and 20% of mutant mice showed hepatic tumors at 25-weeks post-injection; at 36 weeks after treatment, all wild-type and 90% of mutant mice developed tumors
• only 5% of female mutants treated with N-diethynitrosamine develop hepatic tumors by 3 weeks compared to 90% of treated wild-type females
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• treated male mutants show reduced size and lower numbers of tumors than treated wild-type
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• after partial hepatectomy, livers in mutant mice treated with Dipin to induce DNA damage have a considerably lower DNA labeling index compared to wild-type-Dipin PH livers
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