Phenotypes Associated with This Genotype

Genotype
MGI:3619240

• Allelic Composition: Kcnab2^tm1Kmc/Kcnab2^tm1Kmc
• Genetic Background: B6.129S7-Kcnab2^tm1Kmc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:106453 )

• Background Sensitivity: average life span 138 days in B6 congenics

behavior/neurological

tremors ( J:106453 )

• Background Sensitivity: cold induced tremors most severe in the B6 congenic background

homeostasis/metabolism

impaired adaptive thermogenesis ( J:106453 )

• Background Sensitivity: drop in core body temperature due to cold swimming greatest in a B6 congenic background

growth/size/body

decreased body size ( J:106453 )

• mice on a B6 congenic background about 11% smaller than controls, about the size of 129 mice