Phenotypes Associated with This Genotype

Genotype
MGI:3619128

• Allelic Composition: Agt^tm1Unc/Agt^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:24156 )

• postnatal survival is severely compromised, however a few survive to adulthood

homeostasis/metabolism

decreased circulating angiotensinogen level ( J:24156 )

• have no detectable levels of angiotensinogen

cardiovascular system

abnormal kidney vasculature morphology ( J:24156 )

• kidney vessels exhibit thickened walls caused by increased numbers of cells, which appear disorganized

abnormal kidney interlobular artery morphology ( J:24156 )

• defects are most pronounced in interlobular arteries

decreased systemic arterial blood pressure ( J:24156 )

renal/urinary system

abnormal kidney vasculature morphology ( J:24156 )

• kidney vessels exhibit thickened walls caused by increased numbers of cells, which appear disorganized

abnormal kidney interlobular artery morphology ( J:24156 )

• defects are most pronounced in interlobular arteries

tubulointerstitial nephritis ( J:24156 )

• atrophied areas show interstitial infiltration of chronic inflammatory cells

renal interstitial fibrosis ( J:24156 )

• atrophied areas show interstitial fibrosis

kidney atrophy ( J:24156 )

• kidneys exhibit focal areas of severe atrophy

kidney cortex atrophy ( J:24156 )

• generalized cortical thinning with focal areas of severe atrophy

renal tubule atrophy ( J:24156 )

• atrophied areas show shrinkage and loss of tubules

immune system

tubulointerstitial nephritis ( J:24156 )

• atrophied areas show interstitial infiltration of chronic inflammatory cells