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Phenotypes Associated with This Genotype
Genotype
MGI:3619123
Allelic
Composition		 Agttm2Unc/Agt+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agttm2Unc mutation (1 available); any Agt mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating angiotensinogen level ( J:18272 , J:24156 )
• have about 124% of the level of angiotensinogen seen in wild-type (J:18272)

cardiovascular system
increased systemic arterial blood pressure ( J:24156 )
• blood pressure is increased about 8 mmHg compared to wild-type

reproductive system
decreased superovulation rate ( J:69609 )
• exhibit a reduction of ovulatory capacity in response to superovulation, however exhibit normal numbers of follicles, serum estradiol levels and early embryonic development of zygotes

renal/urinary system
renal/urinary system phenotype ( J:24156 )
N
• kidneys, renal plasma flow and glomerular filtration rate are normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory