Mouse Genome Informatics
tg
    Tg(Ins2-NP)25-3Olds/0
involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• 3% of transgenic mice develop diabetes when followed for 10-12 months (J:81284)
• 93% of transgenic mice develop diabetes (hyperglycemia of >250 mg/dl glucose and islets infiltrated with mononuclear cells) after being infected with LCMV (J:81284)
• mice are considered diabetic after a blood glucose measure of >300 mg/dl (J:81287)
• hypoinsulinemia is exhibited by transgenic mice accompanying increased glucose levels and islet infiltration

endocrine/exocrine glands
• pancreata of diabetic transgenic mice show swollen islets with a ground glass appearance (J:81284)
• mononuclear cells begin infiltrating the islets 10 days after viral challenge and are apparent in most transgenic mice after 30 days (J:81284)
• Background Sensitivity: after viral challenge, mononuclear cells infiltrate the islets of transgenic mice bred onto a BALB/c background at 14-21days, while mice bred onto a C57BL/6 background show infiltrates at 21-60 days (J:81284)

immune system
• depletion of CD8+ lymphocytes with a monoclonal antibody inhibited development of diabetes
• 3% of transgenic mice develop diabetes when followed for 10-12 months
• 93% of transgenic mice develop diabetes (evidenced by hyperglycemia with glucose levels of >300 mg/dl and islets infiltrated with mononuclear cells) after being infected with LCMV
• Background Sensitivity: after viral (LCMV) challenge, transgenic mice bred onto a C57BL/6 background develop diabetes in 3-5 months, whereas transgenic mice bred onto a BALB/c background develop diabetes sooner, at 1-2 months

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:81284