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Phenotypes Associated with This Genotype
Genotype
MGI:3618925
Allelic
Composition
Tg(Ins2-NP)25-3Olds/0
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-NP)25-3Olds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 3% of transgenic mice develop diabetes when followed for 10-12 months (J:81284)
• 93% of transgenic mice develop diabetes (hyperglycemia of >250 mg/dl glucose and islets infiltrated with mononuclear cells) after being infected with LCMV (J:81284)
• mice are considered diabetic after a blood glucose measure of >300 mg/dl (J:81287)
• hypoinsulinemia is exhibited by transgenic mice accompanying increased glucose levels and islet infiltration

endocrine/exocrine glands
• pancreata of diabetic transgenic mice show swollen islets with a ground glass appearance (J:81284)
• mononuclear cells begin infiltrating the islets 10 days after viral challenge and are apparent in most transgenic mice after 30 days (J:81284)
• Background Sensitivity: after viral challenge, mononuclear cells infiltrate the islets of transgenic mice bred onto a BALB/c background at 14-21days, while mice bred onto a C57BL/6 background show infiltrates at 21-60 days (J:81284)

immune system
• depletion of CD8+ lymphocytes with a monoclonal antibody inhibited development of diabetes
• 3% of transgenic mice develop diabetes when followed for 10-12 months
• 93% of transgenic mice develop diabetes (evidenced by hyperglycemia with glucose levels of >300 mg/dl and islets infiltrated with mononuclear cells) after being infected with LCMV
• Background Sensitivity: after viral (LCMV) challenge, transgenic mice bred onto a C57BL/6 background develop diabetes in 3-5 months, whereas transgenic mice bred onto a BALB/c background develop diabetes sooner, at 1-2 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:81284


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory