Analysis Tools
mortality/aging
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• about 80% survival rate at 10 months of age
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• about 20% die before 10 months of age
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homeostasis/metabolism
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• myocardial infarct size following 30 min of global ischemia is increased compared to controls
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• following carotid artery ligation the extent of neointimal formation is increased and luminal narrowing is worsened compared to wild-type controls
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• the size of striatal lesions induced by malonate are significantly reduced compared to similarly treated controls
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• insulin resistance in peripheral tissues
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• 24 h after aspiration bulbectomy the number of apoptotic cells in the piriform cortex is reduced compared to similarly treated wild-type mice
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• following occlusion of the middle cerebral artery infarct size is decreased
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nervous system
| N |
• despite the ability of NOS inhibitors to decrease long term potentiation, no significant decrease in long term potentiation is detected at 1 h after tetanus
(J:37956)
• unlike cerebral blood flow, the intensity of neural activation induced by perioral stimulation is not significantly different from controls
(J:84255)
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• 24 h after aspiration bulbectomy the number of apoptotic cells in the piriform cortex is reduced compared to similarly treated wild-type mice
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• the size of striatal lesions induced by malonate are significantly reduced compared to similarly treated controls
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• following occlusion of the middle cerebral artery infarct size is decreased
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• following a theta burst protocol at a weak intensity enhancement of EPSPs during the first 3 minutes after stimulation is significantly small compared to controls
• however, no significant differences are detected when a stronger intensity stimulation is used
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• stimulation of parallel fibers with a 50 msec postsynaptic depolarizations fails to induce long term depression in Purkinje cells
• addition of uncaged NO or photoreleased cGMP to the stimulation protocol also fails to induce long term depression in Purkinje cells, unlike in wild-type mice
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• glutamate release after NMDA stimulation is significantly attenuated in the cerebral cortex, partially reduced in the striatum but unaffected in the hippocampus
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behavior/neurological
| N |
• unlike in earlier reports males show no signs of increased aggression
(J:42548)
• no defects in circadian rhythms are detected in a wheel running assay either under entrained or free running conditions
(J:56005)
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• mice show no improvement in their latency to fall off a pole or plank in the dark versus the light phase, unlike in wild-type controls resulting in deficits in balance compared to wild-type mice during the dark phase
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digestive/alimentary system
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• lower esophageal sphincters fail to display electrical field stimulation (60 V, 5 Hz) induced relaxation or rebound contraction
(J:56948)
• the mean resting lower esophageal sphincter pressure is significantly higher
(J:70182)
• swallowing induced lower esophageal sphincter relaxation is significantly attenuated
(J:70182)
• mice show a range of responses to pharyngeal stimulation including no relaxation, partial relaxation , and sporadic near complete relaxation of the lower esophageal sphincter
(J:70182)
• efferent vagal stimulation induced lower esophageal sphincter relaxation is significantly attenuated
(J:70182)
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immune system
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• dramatic increase in baseline leukocyte adherence
• treatment with an anti-P-selectin antibody significantly reduces the adhesion response in mutant but not in wild-type mice
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• increase in baseline rolling
• treatment with an anti-P-selectin antibody significantly reduces the rolling response in mutant but not in wild-type mice
• treatment with a low dose of thrombin significantly increases rolling in mutant but not in wild-type mice
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• following thioglycollate injection neutrophil accumulation in the peritoneum is significantly enhanced compared to wild-type mice
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muscle
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• the resting membrane potential of jejunal smooth muscle cells is depolarized about 5 mV compared to wild type cells
• hyperpolarization and induction of an inhibitory junction potential in response to electrical field stimulation under nonadrenergic noncholinergic conditions in jejunal muscle strips are markedly reduced
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• lower esophageal sphincters fail to display electrical field stimulation (60 V, 5 Hz) induced relaxation or rebound contraction
(J:56948)
• the mean resting lower esophageal sphincter pressure is significantly higher
(J:70182)
• swallowing induced lower esophageal sphincter relaxation is significantly attenuated
(J:70182)
• mice show a range of responses to pharyngeal stimulation including no relaxation, partial relaxation , and sporadic near complete relaxation of the lower esophageal sphincter
(J:70182)
• efferent vagal stimulation induced lower esophageal sphincter relaxation is significantly attenuated
(J:70182)
|
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• lower esophageal sphincters fail to display electrical field stimulation (60 V, 5 Hz) induced relaxation or rebound contraction
(J:56948)
• the decrease in muscle contractions in jejunal muscle strips in response to electrical field stimulation is markedly reduced
(J:89581)
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cardiovascular system
| N |
• unlike in mice null for Nos3 no significant abnormalities in hypoxic pulmonary vasoconstriction, vasodilation in response to bradykinin, or right ventricle systolic pressure are detected
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• the increase in cerebral blood flow induced by glutamate, perioral stimulation, or harmaline is significantly attenuated
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• in isolated perfused hearts
• however, coronary flow per beat is not significantly different from controls
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• myocardial infarct size following 30 min of global ischemia is increased compared to controls
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• following carotid artery ligation the extent of neointimal formation is increased and luminal narrowing is worsened compared to wild-type controls
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vision/eye
| N |
• no defects are detected in visual acuity
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reproductive system
| N |
• unlike in Nos3 null mice, the increase in maximal penile intracavernous pressure induced by papaverine is not significantly different from wild-type controls
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growth/size/body
cellular
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• the size of striatal lesions induced by malonate are significantly reduced compared to similarly treated controls
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• dramatic increase in baseline leukocyte adherence
• treatment with an anti-P-selectin antibody significantly reduces the adhesion response in mutant but not in wild-type mice
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• increase in baseline rolling
• treatment with an anti-P-selectin antibody significantly reduces the rolling response in mutant but not in wild-type mice
• treatment with a low dose of thrombin significantly increases rolling in mutant but not in wild-type mice
|
hematopoietic system
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• dramatic increase in baseline leukocyte adherence
• treatment with an anti-P-selectin antibody significantly reduces the adhesion response in mutant but not in wild-type mice
|
|
• increase in baseline rolling
• treatment with an anti-P-selectin antibody significantly reduces the rolling response in mutant but not in wild-type mice
• treatment with a low dose of thrombin significantly increases rolling in mutant but not in wild-type mice
|
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• following thioglycollate injection neutrophil accumulation in the peritoneum is significantly enhanced compared to wild-type mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| achalasia | DOID:9164 |
OMIM:200400 |
J:70182 | |
