Mouse Genome Informatics
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• pancreata of males and female show peri-insulitis
• GAD65-reactive T cells from transgenic mice produce significantly lower levels of IFNG than those from NOD controls
• IL-4 levels produced by GAD65 responsive T cells of transgenic mice are 9-fold higher compared to NOD controls
• transgenic mice develop autoimmune pathologies against salivary gland, thyroid and kidney comparable to conrol NOD mice, but no islet-directed autoimmune response is observed
• no males or females develop diabetes (blood glucose >300 mg/dl) during the 40 week evaluation period compared to 60% and 90% incidence in non-transgenic NOD male and female controls respectively
• transgenic mice are almost completely resistant to cyclophosphamide-accelerated diabetes unlike NOD controls

endocrine/exocrine glands
• pancreata of males and female show peri-insulitis

Mouse Models of Human Disease
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:36435