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Phenotypes Associated with This Genotype
Genotype
MGI:3618814
Allelic
Composition
Tg(H2-Ead)5Lt/0
Genetic
Background
NOD/ShiLt-Tg(H2-Ead)5Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(H2-Ead)5Lt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• pancreata of males and female show peri-insulitis (J:36435)
• pancreata of males and female show peri-insulitis (J:36435)
• GAD65-reactive T cells from transgenic mice produce significantly lower levels of IFNG than those from NOD controls (J:36435)
• GAD65-reactive T cells from transgenic mice produce significantly lower levels of IFNG than those from NOD controls (J:36435)
• IL-4 levels produced by GAD65 responsive T cells of transgenic mice are 9-fold higher compared to NOD controls (J:36435)
• IL-4 levels produced by GAD65 responsive T cells of transgenic mice are 9-fold higher compared to NOD controls (J:36435)
• transgenic mice develop autoimmune pathologies against salivary gland, thyroid and kidney comparable to conrol NOD mice, but no islet-directed autoimmune response is observed (J:36435)
• transgenic mice develop autoimmune pathologies against salivary gland, thyroid and kidney comparable to conrol NOD mice, but no islet-directed autoimmune response is observed (J:36435)
• no males or females develop diabetes (blood glucose >300 mg/dl) during the 40 week evaluation period compared to 60% and 90% incidence in non-transgenic NOD male and female controls respectively (J:36435)
• transgenic mice are almost completely resistant to cyclophosphamide-accelerated diabetes unlike NOD controls (J:36435)
• no males or females develop diabetes (blood glucose >300 mg/dl) during the 40 week evaluation period compared to 60% and 90% incidence in non-transgenic NOD male and female controls respectively (J:36435)
• transgenic mice are almost completely resistant to cyclophosphamide-accelerated diabetes unlike NOD controls (J:36435)

endocrine/exocrine glands
• pancreata of males and female show peri-insulitis (J:36435)
• pancreata of males and female show peri-insulitis (J:36435)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:36435


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory