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Phenotypes Associated with This Genotype
Genotype
MGI:3618705
Allelic
Composition
Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background
NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Knw mutation (3 available); any Cd4 mutation (55 available)
Tg(TcraAI4)1Dvs mutation (4 available)
Tg(TcrbAI4)1Dvs mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• transgene-expressing female mice develop IDDM with an onset of about 7 weeks of age, whereas CD4-null NOD mice are resistant (no IDDM by 30 weeks of age)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:93553


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory