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Phenotypes Associated with This Genotype
Genotype
MGI:3618705
Allelic
Composition
Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background
NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Knw mutation (3 available); any Cd4 mutation (53 available)
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• transgene-expressing female mice develop IDDM with an onset of about 7 weeks of age, whereas CD4-null NOD mice are resistant (no IDDM by 30 weeks of age)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory