Mouse Genome Informatics
tg
    Tg(TcrbAI4)1Dvs/0
NOD-Tg(TcrbAI4)1Dvs
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• T cells expressing the transgene comprise ~22% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage

homeostasis/metabolism
• female NOD mice carrying this transgene exhibit a significantly reduced frequency and rate of development of IDDM

immune system
• T cells expressing the transgene comprise ~22% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:93553