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Phenotypes Associated with This Genotype
Genotype
MGI:3618630
Allelic
Composition
Zic3tm1Bca/Y
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic3tm1Bca mutation (0 available); any Zic3 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 30% of males are lost between birth and weaning
• significant lethality seen by E10.5 with continued loss of mice through birth
• this loss is somewhat more severe than in homozygous females
• Background Sensitivity: lethality is more severe in crosses to C57BL/6 compared to outbred Swiss (viability of 0.26 versus 0.46, respectively)

embryo
• failure, delay, or abnormal direction of turning are seen
• some embryos that survive beyond the turning stage show rotation defects including abnormal thoracic and lumbar flexion, and/or abnormal looping of the distal tail (including the hindlimb buds)
• sidedness of the malformations appears to be random
• some embryos with no other gross abnormalities show evidence of growth delay
• seen in some embryos at E8.5
• at E9.5, failure of fusion is seen in some embryos in the midbrain-hindbrain region

nervous system
• seen in some embryos at E8.5
• at E9.5, failure of fusion is seen in some embryos in the midbrain-hindbrain region
• seen in some pups delivered by Ceasarian sections
• abnormal midbrain size and structure in some embryos
• abnormal forebrain size and structure in some embryos
• exencephalic mice have a disorganized basal ganglia
• exencephalic mice have an anteriorly displaced diencephalon
• exencephalic mice have a disorganized thalamus
• exencephalic mice have a disorganized hippocampus
• exencephalic mice have a disorganized cerebral cortex
• seen in exencephalic mice
• seen in a few stillborn pups
• xencephalic mice have rudimentary olfactory nerves

cardiovascular system
• a variety of cardiac defects are seen in a subset of embryos and these embryos always also have other abnormalities
• seen in some embryos
• seen in some embryos
• abnormal systemic venous connections
• one of the most common heart defects is dextro-transposition of the great arteries
• at E10.5 in several embryos the heart is positioned to the left side of the thorax, however in some abnormally turned embryos the heart is properly positioned at the midline and in 2 cases the heart is positioned to the right side of the thorax

respiratory system
• in a few embryos complete lung reversal is seen

digestive/alimentary system
• in some mice right sided stomach is seen

liver/biliary system
• in some mice reversed liver lobation is seen

immune system
• the spleen is always present but often hypoplastic

skeleton
• 10 null mice (includes males and females) had mostly unilateral axial skeletal defects
• partial rib duplications and inappropriately posterior sites of rib insertion are found
• partial duplications and partial fusions are seen
• apparent homeotic transformations

limbs/digits/tail
• all viable males have kinked tails

growth/size/body
• in some mice right sided stomach is seen
• some embryos with no other gross abnormalities show evidence of growth delay
• in a few embryos complete lung reversal is seen

hematopoietic system
• the spleen is always present but often hypoplastic

Mouse Models of Human Disease
OMIM ID Ref(s)
Heterotaxy, Visceral, 1, X-Linked; HTX1 306955 J:75951


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory