Phenotypes Associated with This Genotype

Genotype
MGI:3618585

• Allelic Composition: Crebbp^tm1Jvd/Crebbp^tm1Jvd; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129 * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small thymus ( J:105505 )

increased T cell derived lymphoma incidence ( J:105505 )

• appear as early as 16 weeks of age

increased double-positive T cell number ( J:105505 )

• increased 5 fold

decreased T cell number ( J:105505 )

• reduced about 2 fold in peripheral blood

decreased thymocyte number ( J:105505 )

• total number of thymocytes significantly reduced

decreased CD4-positive, alpha-beta T cell number ( J:105505 )

• reduced in numbers but normal numbers of CD8+ cells

neoplasm

increased T cell derived lymphoma incidence ( J:105505 )

• appear as early as 16 weeks of age

hematopoietic system

small thymus ( J:105505 )

increased T cell derived lymphoma incidence ( J:105505 )

• appear as early as 16 weeks of age

increased double-positive T cell number ( J:105505 )

• increased 5 fold

decreased T cell number ( J:105505 )

• reduced about 2 fold in peripheral blood

decreased thymocyte number ( J:105505 )

• total number of thymocytes significantly reduced

decreased CD4-positive, alpha-beta T cell number ( J:105505 )

• reduced in numbers but normal numbers of CD8+ cells

endocrine/exocrine glands

small thymus ( J:105505 )

decreased thymocyte number ( J:105505 )

• total number of thymocytes significantly reduced

increased T cell derived lymphoma incidence ( J:105505 )

• appear as early as 16 weeks of age