Phenotypes Associated with This Genotype

Genotype
MGI:3618539

• Allelic Composition: Ep300^tm2Pkb/Ep300^tm2Pkb; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small thymus ( J:105505 )

decreased thymocyte number ( J:105505 )

• total number of thymocytes significantly reduced

increased double-positive T cell number ( J:105505 )

• increased 3 fold

decreased single-positive T cell number ( J:105505 )

• half the normal numbers of single positive thymocyte

• proportion of CD4+ to CD8+ is normal in spleen and peripheral blood

hematopoietic system

small thymus ( J:105505 )

decreased thymocyte number ( J:105505 )

• total number of thymocytes significantly reduced

increased double-positive T cell number ( J:105505 )

• increased 3 fold

decreased single-positive T cell number ( J:105505 )

• half the normal numbers of single positive thymocyte

• proportion of CD4+ to CD8+ is normal in spleen and peripheral blood

endocrine/exocrine glands

small thymus ( J:105505 )

decreased thymocyte number ( J:105505 )

• total number of thymocytes significantly reduced