About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3618527
Allelic
Composition
Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic
Background
involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgcdtm1Mcn mutation (1 available); any Sgcd mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• beginning at 8 weeks of age, begin to die suddenly (J:76730)
• premature mortality is also noted at 12, 16, and 28 weeks of age, with a 50% survival rate at 28 weeks of age (J:76730)
• beginning at 8 weeks of age, begin to die suddenly (J:76730)
• premature mortality is also noted at 12, 16, and 28 weeks of age, with a 50% survival rate at 28 weeks of age (J:76730)

muscle
• all skeletal muscles show dystrophic changes (J:76730)
• regional degeneration and regeneration of muscle fibers is common and accompanied by an inflammatory infiltrate (J:76730)
• all skeletal muscles show dystrophic changes (J:76730)
• regional degeneration and regeneration of muscle fibers is common and accompanied by an inflammatory infiltrate (J:76730)
• skeletal and cardiac muscle degeneration (J:76730)
• skeletal and cardiac muscle degeneration (J:76730)
• muscles exhibit pronounced Evans blue dye uptake, indicating alterations in membrane permeability of muscles (J:76730)
• muscles exhibit pronounced Evans blue dye uptake, indicating alterations in membrane permeability of muscles (J:76730)
• beginning at 12 weeks of age, observe signs of cardiac muscle degeneration as indicated by areas of cell death and inflammatory infiltrate (J:76730)
• beginning at 12 weeks of age, observe signs of cardiac muscle degeneration as indicated by areas of cell death and inflammatory infiltrate (J:76730)
• show a 42% drop in force generation over a five eccentric contraction protocol, however twich and tetanic force generation is normal (J:76730)
• show a 42% drop in force generation over a five eccentric contraction protocol, however twich and tetanic force generation is normal (J:76730)

cardiovascular system
• frequent occurrence of perivascular fibrosis (J:76730)
• frequent occurrence of perivascular fibrosis (J:76730)
• beginning at 12 weeks of age, observe signs of cardiac muscle degeneration as indicated by areas of cell death and inflammatory infiltrate (J:76730)
• beginning at 12 weeks of age, observe signs of cardiac muscle degeneration as indicated by areas of cell death and inflammatory infiltrate (J:76730)

homeostasis/metabolism
• elevation in serum creatine kinase levels (J:76730)
• elevation in serum creatine kinase levels (J:76730)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory