Analysis Tools
immune system
| N |
• homozygotes are viable, fertile and overtly normal, with no morphological differences in heart, kidney, spleen, brain, ovary, or testis histology
• importantly, homozygotes display normal B and T cell development, with no significant differences in Ab responses to both thymus-dependent and -independent Ags, serum Ig levels, B lymphopoiesis in fetal liver cultures or in proliferative responses of bone marrow cells to IL-7 and LPS
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