Analysis Tools
mortality/aging
|
• mutants have a median survival of 10.8 months compared to the median survival of 24.2 months shown by wild-type
|
growth/size/body
|
• mice often exhibit hepatomegaly
|
homeostasis/metabolism
|
• starting at 3 months of age, mice present with hemorrhagic ascites
|
neoplasm
|
• necropsy shows large primary tumors and numerous metastases that are solid and cystic in nature and up to several centimeters in diameter on visceral organs and the intraperitoneal space
|
|
• in 2 month old mice, solid or cystic pancreatic adenoma are observed
|
|
• pancreatic cancer found in mutants is predominantly invasive acinar cell carcinoma; mixed carcinomas with acinar and ductal features are observed
|
|
• mice show an increased incidence of this type compared to wild-type
|
|
• mutant mice are often found to have multifocal hepatocellular adenomas
|
endocrine/exocrine glands
|
• metaplastic ductal structures are observed throughout the pancreas in close association with metaplastic acini
|
|
• newborn and adult mice show acinar hyperplasia
|
|
• in 2 month old mice, solid or cystic pancreatic adenoma are observed
|
|
• pancreatic cancer found in mutants is predominantly invasive acinar cell carcinoma; mixed carcinomas with acinar and ductal features are observed
|
digestive/alimentary system
|
• metaplastic ductal structures are observed throughout the pancreas in close association with metaplastic acini
|
|
• newborn and adult mice show acinar hyperplasia
|
liver/biliary system
|
• mice often exhibit hepatomegaly
|
|
• mice show an increased incidence of this type compared to wild-type
|
|
• mutant mice are often found to have multifocal hepatocellular adenomas
|
