Phenotypes Associated with This Genotype

Genotype
MGI:3618353

• Allelic Composition: Supt20^drey/Supt20^drey
• Genetic Background: either: C3.B6-Supt20^drey or (involves: C3H/HeJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:106348 )

• only 4% survive postnatally

pigmentation

abnormal retina pigment epithelium morphology ( J:106348 )

• 79% exhibit expansion of the retinal-pigmented epithelium over the dorsal half of the eye

vision/eye

abnormal retina pigment epithelium morphology ( J:106348 )

• 79% exhibit expansion of the retinal-pigmented epithelium over the dorsal half of the eye

nervous system

open neural tube ( J:106348 )

• in most homozygous mutant embryos the neural tube fails to close completely

spina bifida ( J:106348 )

• 14% exhibit neural tube closure defects consisting of spina bifida

exencephaly ( J:106348 )

• 55% exhibit neural tube closure defects consisting of exencephaly

embryo

failure of initiation of embryo turning ( J:106348 )

• fail to turn; incomplete penetrance

abnormal gastrulation movements ( J:106348 )

• a small proportion of homozygous embryos exhibit defects of gastrulation

abnormal mesoderm development ( J:106348 )

• 3% show severe defects in mesoderm development including a malformed allantois, somite defects, and posterior mesoderm defects

caudal body truncation ( J:106348 )

• a small proportion of embryos exhibit posterior truncation

embryonic growth retardation ( J:106348 )

open neural tube ( J:106348 )

• in most homozygous mutant embryos the neural tube fails to close completely

spina bifida ( J:106348 )

• 14% exhibit neural tube closure defects consisting of spina bifida

abnormal somite development ( J:106348 )

• a small proportion of homozygous embryos exhibit somite defects

abnormal allantois morphology ( J:106348 )

• in a small proportion of mutant embryos the allantois is malformed

growth/size/body

embryonic growth retardation ( J:106348 )