Phenotypes Associated with This Genotype

Genotype
MGI:3618351

• Allelic Composition: Rarb^tm1Vgi/Rarb^tm1Vgi; Rxrb^tm1Rev/Rxrb^tm1Rev
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:51892 )

• mutants display severe impairment in the Morris water maze test and show no improvement in performance over a training period of 8 days; ater 24 hours mutants spend less time in the water where the platform had been in the previous trials compared to wild type controls

nervous system

abnormal excitatory postsynaptic potential ( J:51892 )

• only transient depression of field excitatory postsynaptic potentials is observed in mutants in response to low frequency stimulation, while the controls show a long-lasting depression

reduced long-term potentiation ( J:51892 )

• long term potentiation is absent in hippocampal slices from mutants

absent long-term depression ( J:51892 )

• long term depotentiation can not be induced in mutants