Phenotypes Associated with This Genotype

Genotype
MGI:3618335

• Allelic Composition: Hif1a^tm1.1Mcs/Hif1a⁺
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:105812 )

• although the majority of observed phenotypes do not result in lethality, some embryos do die (stage not specified)

embryo

abnormal embryo development ( J:105812 )

• between E10.5 and E13.5, about 50% of heterozygotes exhibit various developmental defects

cardiovascular system

pericardial effusion ( J:105812 )

• some embryos exhibit cardiac effusion

hemorrhage ( J:105812 )

• some E13.5 embryos exhibit minor hemorrhaging in the embryo and yolk sac

homeostasis/metabolism

pericardial effusion ( J:105812 )

• some embryos exhibit cardiac effusion