Phenotypes Associated with This Genotype

Genotype
MGI:3618333

• Allelic Composition: Tcra^tm1Mjo/Tcra^tm1Mjo
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell number ( J:111129 )

• in spleens compared to heterozygous controls

abnormal T cell morphology ( J:1292 )

• alphabeta+ T cells are completely absent

increased activated T cell number ( J:111129 )

• on average 27% of the gamma-delta T cells are activated

increased immunoglobulin level ( J:111129 )

increased IgE level ( J:111129 )

• in some mice compared to heterozygous controls

increased IgG1 level ( J:111129 )

• in some mice compared to heterozygous controls

abnormal immune system organ morphology ( J:1292 )

abnormal thymus cortex morphology ( J:1292 )

• the cortices of thymi in nulls are greatly expanded and tightly packed with CD4+CD8+ cells

enlarged thymus cortex ( J:1292 )

absent thymus medulla ( J:1292 )

• no medullae are discernible in mutant thymi

abnormal splenic cell ratio ( J:1292 )

• elimination of alphabeta+ T cells is compensated for by an increase in splenic immunoglobulin positive cells (B cells) positive for IgM and IgD

small Peyer's patches ( J:1292 )

• in mutants, these are smaller and shriveled in appearance compared to wild-type, being approximately half the size of controls

increased autoantibody level ( J:111129 )

• about 50% of sera are reactive for mammalian cell proteins compared to only about 11% of sera from heterozygous controls

• reactivity in some mice is primarily against small nuclear ribonucleoproteins

• by 5 weeks of age about 50% of mice show IgG autoantibodies in more than one assay (anti-dsDNA, anti-nuclear antigens, and immunoblotting for antibodies to mammalian cell proteins)

increased anti-nuclear antigen antibody level ( J:111129 )

• more than 80% of sera are positive for anti-nuclear antigens although the degree of reactivity varies

increased anti-double stranded DNA antibody level ( J:111129 )

hematopoietic system

abnormal thymus cortex morphology ( J:1292 )

• the cortices of thymi in nulls are greatly expanded and tightly packed with CD4+CD8+ cells

enlarged thymus cortex ( J:1292 )

absent thymus medulla ( J:1292 )

• no medullae are discernible in mutant thymi

increased B cell number ( J:111129 )

• in spleens compared to heterozygous controls

abnormal T cell morphology ( J:1292 )

• alphabeta+ T cells are completely absent

increased activated T cell number ( J:111129 )

• on average 27% of the gamma-delta T cells are activated

abnormal splenic cell ratio ( J:1292 )

• elimination of alphabeta+ T cells is compensated for by an increase in splenic immunoglobulin positive cells (B cells) positive for IgM and IgD

increased immunoglobulin level ( J:111129 )

increased IgE level ( J:111129 )

• in some mice compared to heterozygous controls

increased IgG1 level ( J:111129 )

• in some mice compared to heterozygous controls

endocrine/exocrine glands

abnormal thymus cortex morphology ( J:1292 )

• the cortices of thymi in nulls are greatly expanded and tightly packed with CD4+CD8+ cells

enlarged thymus cortex ( J:1292 )

absent thymus medulla ( J:1292 )

• no medullae are discernible in mutant thymi