Phenotypes Associated with This Genotype

Genotype
MGI:3618332

• Allelic Composition: Hif1a^tm1.1Mcs/Hif1a^tm1.1Mcs
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:105812 )

• about 2/3 cannot be recovered at E6.5-E7.5

embryo

abnormal embryo development ( J:105812 )

• 10% of E6.5-E7.5 embryos fail to form typical extraembryonic and embryonic cavities

abnormal developmental patterning ( J:105812 )

• aberrant temporal and spatial expression of mesodermal and visceral endoderm markers, suggesting that embryos fail to maintain normal patterning of embryonic and extraembryonic tissues

embryonic growth arrest ( J:105812 )

• arrest development around the time of mesoderm formation

abnormal embryonic epiblast morphology ( J:105812 )

• improper formation of the epiblast

• 10% of E6.5-E7.5 embryos exhibit an expansion of the epiblast