Phenotypes Associated with This Genotype

Genotype
MGI:3618330

• Allelic Composition: Cd80^tm1Shr/Cd80^tm1Shr; Cd86^tm2Shr/Cd86^tm2Shr
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased regulatory T cell number ( J:113109 , J:205441 )

• mice have 0.3% CD4+CD25^hiCD62L+ regulatory T cells compared to 4% in NOD controls (J:113109)

• in the thymus (J:205441)

abnormal spleen morphology ( J:39089 )

• after immunization with complete Freund's adjuvant, spleens examined 7-10 days later were significantly smaller than wild-type

increased IgG3 level ( J:39089 )

• mutants have a 3 to 5-fold elevation in IgG3

decreased IgG level ( J:39089 )

• unimmunized mice show a 2 to 5-fold reduction in total serum IgG and IgG2a and a 5 to 10-fold reduction in IgG1

decreased IgG1 level ( J:39089 )

decreased IgG2a level ( J:39089 )

increased IgM level ( J:39089 )

• mutants have a 3 to 5-fold elevation in IgM

abnormal T cell physiology ( J:57090 )

• cells secrete more interferon gamma and less Il-4 than Ctla4-null cells

abnormal T cell proliferation ( J:57090 )

• during primary response after antigen stimulation, T cells produce less than cells that are additionally Ctla4-null

abnormal lymph node B cell domain morphology ( J:39089 )

• lymphoid follicles are small, resembling primary follicles without recognizable germinal centers

increased susceptibility to autoimmune diabetes ( J:113109 )

• 100% of mice develop diabetes by 17 weeks

hematopoietic system

decreased regulatory T cell number ( J:113109 , J:205441 )

• mice have 0.3% CD4+CD25^hiCD62L+ regulatory T cells compared to 4% in NOD controls (J:113109)

• in the thymus (J:205441)

abnormal spleen morphology ( J:39089 )

• after immunization with complete Freund's adjuvant, spleens examined 7-10 days later were significantly smaller than wild-type

increased IgG3 level ( J:39089 )

• mutants have a 3 to 5-fold elevation in IgG3

decreased IgG level ( J:39089 )

• unimmunized mice show a 2 to 5-fold reduction in total serum IgG and IgG2a and a 5 to 10-fold reduction in IgG1

decreased IgG1 level ( J:39089 )

decreased IgG2a level ( J:39089 )

increased IgM level ( J:39089 )

• mutants have a 3 to 5-fold elevation in IgM

abnormal T cell physiology ( J:57090 )

• cells secrete more interferon gamma and less Il-4 than Ctla4-null cells

abnormal T cell proliferation ( J:57090 )

• during primary response after antigen stimulation, T cells produce less than cells that are additionally Ctla4-null

cellular

abnormal T cell proliferation ( J:57090 )

• during primary response after antigen stimulation, T cells produce less than cells that are additionally Ctla4-null