Phenotypes for Lfng MGI:3618278 MGI Mouse

embryonic lethality, incomplete penetrance ( J:146621 )

• homozygotes die late in embryonic lethality

skeleton phenotype ( J:48859 )

N

abnormal axial skeleton morphology ( J:48859 )

rib fusion ( J:48859 )

abnormal vertebrae development ( J:48859 )

• incompletely formed vertebrae

abnormal vertebral body development ( J:48859 )

vertebral fusion ( J:48859 )

abnormal embryo development ( J:48859 )

abnormal rostral-caudal patterning of the somites ( J:48859 )

• failure of caudal and rostral spatial definition of half-somites

abnormal embryonic hematopoiesis ( J:146621 )

• when mutant fetal liver cells is mixed 1:1 with wild-type bone marrow and transferred into lethally irradiated hosts, there is a slight reduction in the number of marginal zone B cells generated compared to controls

abnormal female reproductive system morphology ( J:96967 )

• reproductive tracts of 4 and 7 week old null mice are smaller than heterozygous littermates

abnormal ovarian follicle morphology ( J:96967 )

• sexually mature mice had normal follicles of all sizes and abnormal follicles

abnormal ovarian folliculogenesis ( J:96967 )

impaired ovarian folliculogenesis ( J:96967 )

small ovary ( J:96967 )

• ovaries of 4 and 7 week old null mice are smaller than heterozugous littermates

abnormal gametogenesis ( J:96967 )

abnormal oocyte morphology ( J:96967 )

• after induced ovulation and fertilization, only 9.7% of eggs became 2-cell embryos compared to 48.8% of controls

• only 2% of embryos became 4 to 8 cell embryos and none reached the blastocyst stage compared to 31.4% of controls that reached blastocysts stage

abnormal female meiosis ( J:96967 )

• oocytes do not complete meiotic maturation

female infertility ( J:96967 )

• all females found infertile due to defects in meiotic maturation