Mouse Genome Informatics
ht
    Atp7aMo-Tohm/Atp7a+
B6.Cg-Atp7aMo-Tohm
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: 84.2% of females die within 2 days after birth, with the rest surviving to adulthood

growth/size/body
• exhibit slow growth at the age of 15 days

behavior/neurological
• exhibit a motor disorder at 15 days of age

cardiovascular system
• elastin fibers of the descending aorta are fragmented
• 32 of 38 female pups have hemorrhages involving the shoulder, upper extremity and head and died 2 days after birth

cellular
• increase in apoptosis in the brain

homeostasis/metabolism
• copper content in the brains of 4 week old females is significantly lower

nervous system
• copper content in the brains of 4 week old females is significantly lower
• increase in apoptosis in Ammon's horn
• increase in apoptosis in the cerebral cortex, excluding the molecular layer
• Purkinje cells with a small amount of cytoplasm and apoptotic bodies
• increase in apoptosis in the granular layer of the cerebellum

pigmentation

integument

Mouse Models of Human Disease
OMIM IDRef(s)
Menkes Disease 309400 J:105797