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Phenotypes Associated with This Genotype
Genotype
MGI:3618244
Allelic
Composition
Atp7aMo-Tohm/Atp7a+
Genetic
Background
B6.Cg-Atp7aMo-Tohm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-Tohm mutation (1 available); any Atp7a mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: 84.2% of females die within 2 days after birth, with the rest surviving to adulthood

growth/size/body
• exhibit slow growth at the age of 15 days

behavior/neurological
• exhibit a motor disorder at 15 days of age

cardiovascular system
• elastin fibers of the descending aorta are fragmented
• 32 of 38 female pups have hemorrhages involving the shoulder, upper extremity and head and died 2 days after birth

cellular
• increase in apoptosis in the brain

homeostasis/metabolism
• copper content in the brains of 4 week old females is significantly lower

nervous system
• increase in apoptosis in the brain
• copper content in the brains of 4 week old females is significantly lower
• increase in apoptosis in Ammon's horn
• increase in apoptosis in the cerebral cortex, excluding the molecular layer
• Purkinje cells with a small amount of cytoplasm and apoptotic bodies
• increase in apoptosis in the granular layer of the cerebellum

pigmentation

integument

Mouse Models of Human Disease
OMIM ID Ref(s)
Menkes Disease 309400 J:105797


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory