Mouse Genome Informatics
ht
    Atp7aMo-Tohm/Atp7a+
B6.Cg-Atp7aMo-Tohm
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• Background Sensitivity: 84.2% of females die within 2 days after birth, with the rest surviving to adulthood (J:105797)

growth/size
• exhibit slow growth at the age of 15 days (J:105797)

behavior/neurological
• exhibit a motor disorder at 15 days of age (J:105797)

cardiovascular system
• elastin fibers of the descending aorta are fragmented (J:105797)
• 32 of 38 female pups have hemorrhages involving the shoulder, upper extremity and head and died 2 days after birth (J:105797)

cellular
• increase in apoptosis in the brain (J:105797)

homeostasis/metabolism
• copper content in the brains of 4 week old females is significantly lower (J:105797)

nervous system
• copper content in the brains of 4 week old females is significantly lower (J:105797)
• increase in apoptosis in Ammon's horn (J:105797)
• increase in apoptosis in the cerebral cortex, excluding the molecular layer (J:105797)
• Purkinje cells with a small amount of cytoplasm and apoptotic bodies (J:105797)
• increase in apoptosis in the granular layer of the cerebellum (J:105797)

pigmentation
(J:105797)

integument
(J:105797)

Mouse Models of Human Disease
OMIM IDRef(s)
Menkes Disease 309400 J:105797