Phenotypes Associated with This Genotype

Genotype
MGI:3618242

• Allelic Composition: Atp7a^Mo-Tohm/Y
• Genetic Background: B6.Cg-Atp7a^Mo-Tohm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:105797 )

♂ • Background Sensitivity: most males die between E10.5 and E11.5 and all are dead by E12.5, slightly earlier than on an ICR background

embryo

abnormal vitelline vasculature morphology ( J:105797 )

♂ • exhibit hemorrhage occurring from the yolk sac vessels

abnormal visceral yolk sac morphology ( J:105797 )

♂ • irregular attachment between the mesoderm and the endothelial cells in the yolk sac

♂ • haphazard disruption of type I collagen fibers in the yolk sac

♂ • cells of the yolk sac at E10.5 are irregularly shaped

abnormal vitelline vascular remodeling ( J:105797 )

♂ • exhibit hypoplasia, arrested development, and a remodeling defect in yolk sac blood vessels

cardiovascular system

abnormal vitelline vasculature morphology ( J:105797 )

♂ • exhibit hemorrhage occurring from the yolk sac vessels

hemorrhage ( J:105797 )

♂ • massive hemorrhage and blood cells in the yolk sac cavity, but not the embryo proper