Phenotypes Associated with This Genotype

Genotype
MGI:3618223

• Allelic Composition: Gli3^Xt-J/Gli3^Xt-J
• Genetic Background: involves: C3H/HeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:42454 )

N • Background Sensitivity: homozygotes survive beyond E14.5 and up to birth at least

endocrine/exocrine glands

abnormal mammary gland bud morphology ( J:112460 )

♀ • at 13.5, all lack of mammary bud pair number 5 and most lack bud number 3; a small proportion show reduction and/or misplacement of bud number 3

respiratory system

abnormal left lung morphology ( J:42454 )

• left lobe reduced in both width and length

abnormal right lung accessory lobe morphology ( J:42454 )

• accessory lobe reduced in both width and length

abnormal right lung caudal lobe morphology ( J:42454 )

• reduced width but not length in right caudal lobe

small lung ( J:42454 )

• lungs small in all homozygotes from E17.5 through to newborn pups

integument

abnormal mammary gland bud morphology ( J:112460 )

♀ • at 13.5, all lack of mammary bud pair number 5 and most lack bud number 3; a small proportion show reduction and/or misplacement of bud number 3