Analysis Tools
mortality/aging
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• at weaning, homozygotes are obtained at a significantly reduced Mendelian frequency
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renal/urinary system
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• 2 out of 2 mutant kidneys exhibit vascular hyperplasia
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• 2 out of 2 mutant kidneys show cortical atrophy
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reproductive system
| N |
• unlike Acetm1Unc homozygotes lacking both isozymes which display reduced male fertility, male homozygotes that lack the somatic isoform but retain the testicular isoform display normal fertility with no sperm defects in the zona pellucida binding assay
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cardiovascular system
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• 2 out of 2 mutant kidneys exhibit vascular hyperplasia
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