About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3618139
Allelic
Composition
Snrpntm2Cbr/Snrpn+
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snrpntm2Cbr mutation (1 available); any Snrpn mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 72% of heterozygotes die within 48 hours of birth with none surviving past 7 days of age
• less than 5% of mice heterozygous for the paternally inherited deletion allele alone survive to weaning

behavior/neurological
• heterozygotes are capable of suckling but consistently have less milk in their stomachs compared to wild-type littermates
• mice that survive past 2 days display weakness
• heterozygotes are unable to support themselves on their hind feet and instead rest on their knees

growth/size/body
• on the day of birth heterozygotes appear normal but weigh about 20% less than wild-type littermates
• mice that survive past 2 days fail to maintain normal growth rates

homeostasis/metabolism
• mice that survive past 2 days appear dehydrated

reproductive system
N
• no genital or gonadal hypoplasia is seen at birth

cellular
• in J:47318 all heterozygotes carry a paternally inherited mutant allele (J:47318)

Mouse Models of Human Disease
OMIM ID Ref(s)
Prader-Willi Syndrome; PWS 176270 J:47318


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory