Mouse Genome Informatics
ht
    Snrpntm2Cbr/Snrpn+
involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 72% of heterozygotes die within 48 hours of birth with none surviving past 7 days of age
• less than 5% of mice heterozygous for the paternally inherited deletion allele alone survive to weaning

behavior/neurological
• heterozygotes are capable of suckling but consistently have less milk in their stomachs compared to wild-type littermates
• mice that survive past 2 days display weakness
• heterozygotes are unable to support themselves on their hind feet and instead rest on their knees

growth/size
• on the day of birth heterozygotes appear normal but weigh about 20% less than wild-type littermates
• mice that survive past 2 days fail to maintain normal growth rates

homeostasis/metabolism
• mice that survive past 2 days appear dehydrated

reproductive system
N
• no genital or gonadal hypoplasia is seen at birth (J:47318)

cellular
• in J:47318 all heterozygotes carry a paternally inherited mutant allele (J:47318)

Mouse Models of Human Disease
OMIM IDRef(s)
Prader-Willi Syndrome; PWS 176270 J:47318