Phenotypes Associated with This Genotype

Genotype
MGI:3618094

• Allelic Composition: Kcnn2^tm2Jpad/Kcnn2⁺
• Genetic Background: B6.129S4-Kcnn2^tm2Jpad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synaptic transmission ( J:105645 )

• four fold increase in the amplitude of apamin sensitive currents in CA1 neurons

abnormal excitatory postsynaptic potential ( J:105645 )

• EPSP in CA1 neurons increases136% as opposed to 59% for controls after apamin treatment

• no effect on paired-pulse facilitation

reduced long-term potentiation ( J:105645 )

• LTP induced by three 50Hz tetani was significantly reduced

behavior/neurological

abnormal contextual conditioning behavior ( J:105645 )

abnormal cued conditioning behavior ( J:105645 )

abnormal spatial learning ( J:105645 )

• longer cumulative distance to target in Morris water maze tests