Phenotypes Associated with This Genotype

Genotype
MGI:3617996

• Allelic Composition: Tg(TcraCl1,TcrbCl1)1Shrm/0
• Genetic Background: B10.Cg-Thy1^a H2^d Tg(TcraCl1,TcrbCl1)1Shrm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell subpopulation ratio ( J:97745 )

• mice hemizygous for this transgene exhibit skewing of thymic and lymph node T cell populations toward the CD8⁺ compartment

reproductive system

abnormal fertility/fecundity ( J:106230 )

• pregnant hemizygous female mice usually die before giving birth

neoplasm

increased tumor incidence ( J:106230 )

• some, but not all, hemizygous transgenic mice develop tumors at 5-6 months of age

hematopoietic system

abnormal T cell subpopulation ratio ( J:97745 )

• mice hemizygous for this transgene exhibit skewing of thymic and lymph node T cell populations toward the CD8⁺ compartment

behavior/neurological

weakness ( J:106230 )

• female mice hemizygous for this transgene exhibit general physiological weakness