Phenotypes Associated with This Genotype

Genotype
MGI:3617774

• Allelic Composition: Cxcr4^tm1Qma/Cxcr4^tm1Qma; Gab1^tm1Wbm/Gab1^tm1Wbm
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle precursor cell migration ( J:100909 )

• at E10.75 and E11.5, no hypaxial muscle progenitor cells reach the floor of the first branchial arch

abnormal intrinsic tongue muscle morphology ( J:100909 )

• only a fragment of the intrinsic muscle is present in the proximal tongue

abnormal myogenesis ( J:100909 )

• at E10.75, the number of muscle cells (MyoD+) is further reduced and the number of apoptotic cells is increased in the dorsal and ventral limbs compared to Gab single homozygotes

hypaxial muscle hypoplasia ( J:100909 )

• limb muscle size is reduced and in the proximal portion of the lower forelimb, particular extensor muscles of dorsal limb are absent and the flexor muscles are reduced in size compared to Gab1 single homozygotes

digestive/alimentary system

abnormal intrinsic tongue muscle morphology ( J:100909 )

• only a fragment of the intrinsic muscle is present in the proximal tongue

decreased tongue size ( J:100909 )

• the overall size of the tongue is very small

craniofacial

abnormal intrinsic tongue muscle morphology ( J:100909 )

• only a fragment of the intrinsic muscle is present in the proximal tongue

decreased tongue size ( J:100909 )

• the overall size of the tongue is very small

cellular

abnormal muscle precursor cell migration ( J:100909 )

• at E10.75 and E11.5, no hypaxial muscle progenitor cells reach the floor of the first branchial arch

growth/size/body

abnormal intrinsic tongue muscle morphology ( J:100909 )

• only a fragment of the intrinsic muscle is present in the proximal tongue

decreased tongue size ( J:100909 )

• the overall size of the tongue is very small