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Phenotypes Associated with This Genotype
Genotype
MGI:3617447
Allelic
Composition
Fahtm1Mgo/Fahtm1Mgo
Genetic
Background
involves: 129S7/SvEvBrd * PT
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fahtm1Mgo mutation (0 available); any Fah mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Liver disease in Fahtm1Mgo/Fahtm1Mgo mice and liver histology of Fahtm1Mgo/Fahtm1Mgo Hgdaku/Hgdaku and Fahtm1Mgo/Fahtm1Mgo Hgdaku/Hgd+ mice after treatment with the drug NTCB

homeostasis/metabolism
• plasma tyrosine levels become elevated after withdrawal from 2-(2-N-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC)

liver/biliary system
• after withdrawal from NTBC
• abnormal liver function
• after withdrawal from NTBC

renal/urinary system
• after withdrawal from NTBC
• after withdrawal from NTBC

growth/size/body
• lose weight and become sick after withdrawal from NTBC

immune system
• after withdrawal from NTBC

Mouse Models of Human Disease
OMIM ID Ref(s)
Tyrosinemia, Type I; TYRSN1 276700 J:77295


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory