Mouse Genome Informatics
hm
    Fahtm1Mgo/Fahtm1Mgo
involves: 129S7/SvEvBrd * PT
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Liver disease in Fahtm1Mgo/Fahtm1Mgo mice and liver histology of Fahtm1Mgo/Fahtm1Mgo Hgdaku/Hgdaku and Fahtm1Mgo/Fahtm1Mgo Hgdaku/Hgd+ mice after treatment with the drug NTCB

homeostasis/metabolism
• plasma tyrosine levels become elevated after withdrawal from 2-(2-N-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC)

liver/biliary system
• after withdrawal from NTBC
• abnormal liver function
• after withdrawal from NTBC

renal/urinary system
• after withdrawal from NTBC
• after withdrawal from NTBC

growth/size/body
• lose weight and become sick after withdrawal from NTBC

immune system
• after withdrawal from NTBC

Mouse Models of Human Disease
OMIM IDRef(s)
Tyrosinemia, Type I; TYRSN1 276700 J:77295