Phenotypes Associated with This Genotype

Genotype
MGI:3617360

• Allelic Composition: Hmgn1^tm1Mbus/Hmgn1^tm1Mbus
• Genetic Background: either: (involves: 129/Sv * 129X1/SvJ) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:100282 )

• at E11.5 only 8% of mice are homozygous rather than the expected 25%

cellular

abnormal cell physiology ( J:100282 )

• in primary MEFs, the removal of UV induced cyclobutane pyrimidine dimers is slower than in wild-type cells

increased cellular sensitivity to ultraviolet irradiation ( J:100282 )

• primary MEFs are more sensitive to UV-C irradiation induced death (D50 = 3 J/m2 compared to 13.5 J/m2 for wild-type cells)

integument

increased sensitivity to skin irradiation ( J:100282 )

• a cumulative UV-B dose of 1200 J/m2 produces skin alterations including acanthosis and localized hyperkeratosis in homozygotes but not in wild-type mice