Phenotypes Associated with This Genotype

Genotype
MGI:3617312

• Allelic Composition: Rbp7^tm1Vgl/Rbp7^tm1Vgl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal vitamin A level ( J:100844 )

• retinyl ester levels in the milk are reduced with the greatest reduction seen in retinyl palmitate levels

• at weaning but not at 11 or 17 weeks of age, total retinol levels in the heart are reduced; however no difference in retinoid uptake is seen in the heart, mammary gland, or adipose tissue

• at 11 weeks of age retinol and retinyl ester levels are reduced in the mammary gland; only levels of specific retinyl ester (retinyl palmitate) are reduced

• at 17 weeks of age retinol but not retinyl ester levels are reduced in the mammary gland