Analysis Tools
mortality/aging
|
• all die by E13.5, with abnormalities evident at E9.5 but not E9
|
growth/size/body
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• smaller than controls, probably due to lack of blood flow, however they develop to the correct developmental stage
|
cardiovascular system
|
• significant thinning of the myocardial layer in the ventricles
|
small heart
(
J:104114
)
|
• heart mass is smaller in E9.5 embryos and by E13.5, most homozygotes lack any visible signs of a heart
|
|
• one of the E13.5 embryos that still has a heart shows abnormal trabeculation in the ventricle and abnormal ventricular wall structure
|
|
• hearts fail to function properly as indicated by blood leaking outside the heart and the backup of blood in the atrium
|
|
• decrease in blood flow that results in congestion and backup of blood in other organs
|
hemorrhage
(
J:104114
)
|
• exhibit blood leaking outside the heart
|
muscle
|
• significant thinning of the myocardial layer in the ventricles
|
embryo
|
• smaller than controls, probably due to lack of blood flow, however they develop to the correct developmental stage
|
cellular
