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Phenotypes Associated with This Genotype
Genotype
MGI:3616434
Allelic
Composition		 Tg(Otx1-cre)1Eag/0
Wnt3atm2Eag/Wnt3a+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Otx1-cre)1Eag mutation (0 available)
Wnt3atm2Eag mutation (0 available); any Wnt3a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cortical marginal zone morphology ( J:104373 )
• numbers of Cajal-Retzius cells in neocortical layer are greatly reduced and remaining cells are dispersed
decreased Cajal-Retzius cell number ( J:104373 )
• numbers of Cajal-Retzius cells in neocortical layer are greatly reduced
abnormal cerebral cortex morphology ( J:104373 )
• cortical hem is present, but smaller than normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory